[Sepsis] Early Goal

但若是septic shock或severe sepsis without shock則希望把antibiotic administration的時間縮短為1個小時AFTER recognition

若SCVO₂ <70%或S_VO2 <65% despite adequate intravascular volume repletion, 則考慮：

1.     Dobutamine infusion       (max: 20 mcg/kg/min)

2.     pRBC transfusion             (target Hct > 30%)

Mechanical ventilated or known preexisting decreased ventricular compliance則建議把CVP設定為12~15 mmHg

[Sepsis] Surviving Sepsis Guideline 2012 - Definition

1. Sepsis      = Infection + Systemic manifestations of infection

2. SEVERE sepsis  = Sepsis + Organ Dysfunction or Tissue Hypoperfusion

3. Sepsis induced HYPOTENSION   = SBP < 90 or MAP < 70 or SBP decrease > 40 or less than two SD below normal for age

4. Septic SHOCK   = Sepsis induced hypotension, persisting DESPITE ADEQUATE FLUID RESUSCITATION

5. Sepsis induced TISSUE HYPOPERFUSION = SEPTIC SHOCK, # LACTATE (> 4 mmol/L) or OLIGURIA